In August 2018, there have been Nearly a person hundred overdose instances documented around two days in New Haven, Connecticut from a poor batch of K2. The artificial cannabinoid was considered to have already been mixed with fentanyl, although no fentanyl was identified in samples of the drug examined via the DEA.[111]

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PB-22 and 5F-PB-22 ended up the main synthetic cannabinoids to include a quinoline substructure and an ester linkage. These compounds are believed to have been synthesized Using the intention of making a artificial cannabinoid prodrug, which could strengthen absorption and confound detection. Ester bonds are very easily biodegradable as a result of spontaneous or endogenous, nonspecific esterase hydrolysis, that has been usually Employed in medicinal chemistry to help make ester prodrugs.